TB-500: A Comprehensive Guide to Thymosin Beta-4 for Research

What is TB-500?

TB-500 is a synthetic peptide derived from Thymosin Beta-4 (TB4), a naturally occurring protein present in virtually all human and animal cells. As a research peptide, TB-500 has garnered significant attention in laboratory and academic settings for its potential applications in tissue repair and regeneration studies.

Molecular Structure and Mechanism

TB-500 is composed of 43 amino acids and represents the active region of the larger TB4 protein. Research suggests it may influence cellular migration, differentiation, and angiogenesis through actin regulation pathways. These mechanisms make it a valuable tool for researchers studying wound healing and tissue regeneration processes.

Research Applications

Current laboratory research with TB-500 focuses on several key areas:

• Tissue Repair Studies: Investigating cellular mechanisms involved in wound healing and tissue regeneration
• Inflammation Research: Examining anti-inflammatory pathways and immune response modulation
• Cardiovascular Studies: Exploring angiogenesis and vascular development in controlled settings
• Musculoskeletal Research: Analyzing connective tissue repair and cellular differentiation

Storage and Handling

For optimal stability, TB-500 should be stored as a lyophilized powder at -20°C. Once reconstituted with bacteriostatic water, the peptide should be refrigerated at 2-8°C and used within the recommended timeframe. Always follow proper laboratory protocols when handling research peptides.

Quality Assurance

All TB-500 products from US Peptide Research include third-party testing and a Certificate of Analysis (COA) to verify purity and composition. This documentation is essential for maintaining research integrity and ensuring reproducible results.

Research Considerations

When designing studies involving TB-500, researchers should consider:

• Proper reconstitution techniques and concentration calculations
• Storage conditions to maintain peptide stability
• Documentation of batch numbers and COA data
• Adherence to institutional research protocols

Conclusion

TB-500 continues to be a valuable tool in peptide research, offering insights into cellular repair mechanisms and tissue regeneration pathways. As with all research peptides, proper handling, storage, and documentation are essential for achieving reliable and reproducible results.

Note: TB-500 is intended for laboratory research purposes only and is not approved for human or veterinary use.